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Head of Regeneron Cell Medicines
Head of Regeneron Cell Medicines
Location: Cambridge, MA (primary site)
The Head of Regeneron Cell Medicines (RCM) sets the vision, strategy, and execution for Regeneron’s cell medicines portfolio and technology platform. Scope includes ex vivo and in vivo CAR T programs and enabling technologies for delivery, including chemo-free conditioning. This leader oversees cross-functional initiatives from discovery through early clinical development, builds and mentors high-performing teams, and partners across the enterprise and with external collaborators to deliver transformative cell-based therapies. Based in Cambridge, MA, this role serves as the site’s senior scientific executive and advances the RCM portfolio in alignment with Regeneron’s broader scientific vision.
In This Role, You Will:
Strategy and Portfolio Leadership
- Define and drive the long-term scientific vision and portfolio strategy for ex vivo and in vivo cell medicines, aligned to enterprise priorities.
- Prioritize programs and platform investments using data-driven governance, scenario planning, and risk/benefit frameworks.
- Champion innovation in cell engineering, in vivo delivery (e.g., LNPs, viral vectors), and manufacturing to create differentiated therapies.
- Establish and evolve the CAR T strategy, including target selection, tissue/cell targeting, potency enhancement, and combinations with antibody-based approaches.
Scientific Program Oversight
- Lead matrixed teams to deliver milestones from target validation to IND, Phase I manufacturing, and early clinical readouts.
- Guide technical problem solving across modalities, including CAR T design, delivery optimization, biodistribution/PK, on/off-target assessment, and safety risk mitigation.
- Integrate enabling platforms where justified (e.g., CAR Ts, antibody-based approaches such as CPIs and bispecifics, encoded potency enhancements, ARMoR’ing strategies).
- Drive benign conditioning initiatives that enable chemo-free delivery of cell-based medicines (including T cells and hematopoietic stem cells).
People Leadership and Organizational Development
- Build, mentor, and retain a diverse, high-performing organization of senior scientific leaders and functional experts.
- Foster a culture of scientific excellence, accountability, collaboration, and inclusion across sites and functions.
- Implement succession planning, talent development, and performance management.
Cross-Functional and Cross-Site Collaboration
- Partner closely with Research, Preclinical Development, Clinical, Regulatory, Quality, CMC, Manufacturing, BD, and Finance.
- Serve as the senior scientific leader for the Cambridge site; maintain strong operating rhythms with Seattle and Tarrytown leadership.
- Coordinate with vector/delivery, immunology, and translational biomarker teams to accelerate RCM programs to clinical evaluation.
External Innovation and Partnerships
- Identify and evaluate external opportunities (academia, biotech, consortia, platforms) to accelerate the pipeline and capabilities.
- Negotiate and govern collaborations to clear, value-creating outcomes.
Operational Excellence and Compliance
- Own budgets, headcount planning, and resource allocation across programs and platform functions.
- Ensure adherence to biosafety, ethical guidelines, and regulatory standards (e.g., IND enabling, GxP interfaces), including nonclinical programs specific to ex vivo and in vivo cell therapy (biodistribution, preclinical safety).
- Drive reproducibility, data integrity, and robust decision records.
Executive Communication and Governance
- Provide clear, concise updates to executive leadership and governance bodies on strategy, progress, risks, and mitigation plans.
- Represent Regeneron Cell Medicines at internal and external forums, scientific conferences, and with partners.
What You Need to Succeed:
Required Qualifications
- Advanced degree (PhD, MD, or MD/PhD) in cell biology, immunology, bioengineering, or related discipline.
- 20+ years of biopharmaceutical R&D experience with a substantial focus on cell-based therapies; track record advancing programs from discovery to IND and early clinical.
- Demonstrated leadership of multidisciplinary, multisite teams and senior people leaders in a fast-paced environment.
- Deep expertise across key domains:
- Cell engineering (e.g., CAR design, viral vectors), potency/identity assays, process and analytical development, and translational biology.
- In vivo gene delivery for in vivo CAR T, including viral and non-viral modalities (e.g., LVV, LNPs), tissue/cell targeting strategies, biodistribution/PK, on/off-target risk assessment, and immunogenicity management.
- CMC considerations for in vivo modalities (vector design, release testing, stability) versus ex vivo products.
- Familiarity with regulatory pathways for cell and gene therapies (e.g., FDA/EMA guidance, IND preparation, RMAT considerations), including in vivo gene therapy nonclinical packages (biodistribution, toxicology, shedding).
- Strong portfolio management, resource planning, and financial acumen.
- Exceptional communication, influence, and stakeholder management; effective in executive forums and cross-functional decision making.
- Commitment to building an inclusive culture and developing talent.
Leadership Competencies
- Strategic vision and critical thinking that drive high-quality decisions.
- Scientific rigor and an innovation mindset, balanced by a patient-centric bias for action.
- Talent development and coaching.
- Cross-functional collaboration and influence beyond direct reporting lines.
- Results orientation and accountability.
- Change leadership and resilience.
Work Model
- On-site presence 4+ days per week in Cambridge, MA; regular travel to Tarrytown, NY and Seattle, WA.
Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.
For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.
Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.
Salary Range (annually)
